The low bioavailability and ocular residence time exhibited by the topical conventional liquid ophthalmic formulations because of spillage by overflow, dilution of drug by tear turn over, nacolacrimal drainage and systemic absorption may be overcome by the use of in-situ forming system that are instilled as liquid into the cul-de-sac of the eye. The present work made to attempt and ophthalmic controlled drug delivery system of an anti-bacterial agent, levofloxacin base on the concept of pH induced in-situ gellation. The acrypol 941 and 980 (carbopol grade) use as a gelling agent with viscolyzers like methyl cellulose, hydroxy ethyl cellulose, hydroxyl propyl methyl cellulose (K 15) was added for ocular viscosity enhancing agent. Formulation was evaluated for drug content uniformity, viscosity, in-vitro gellation study and in-vitro released study. The rheological behavior of gel formulation was not affected by in corporation of levofloxacin. The result demonstrates that formulation contains the acrypol 980 /HPMC mixture can be used as in-situ gelling vehicle to enhance ocular bioavailability and patient compliance.
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